Preparative column

VDSpher has proven itself not only in the analytical scale, but also for the semi-preparative and preparative HPLC. Customers from all areas of research & development as well as from quality control of research facilities to large enterprises of the chemical and pharmaceutical industry use different VDSpher modifications in order to purify and analyse their substances. The excellent scalability enables the simple switching from small particle diameters (1.8 µm to 5 µm) to larger particle sizes (7 µm, 10 µm, 15 µm, 30 µm and beyond) preferred in semi-preparative and preparative applications. Some VDSpher Classic modifications are available with a pore diameter of 75 Å. The high surface of these materials of 500 m2/g offers the advantage of very high sample loading, so that time and money can be saved during purification. All VDSpher Classic & PUR silica gels can be used in the semi-preparative and preparative scale. To achieve the best possible column packing we recommend VDSpher Classic phases especially for columns with 20 mm or higher inner diameter.

Normally Available Column Dimensions for Semi-Preparative and Preparative Applications

We would also like to focus on some VDSpher PUR modifications which are available for selection in a particle size of 7 µm. This particle size represents a valuable compromise between 5 µm and 10 µm: Less pressure than with 5 µm – more plates numbers than 10 µm.

In brief: Anyone who still has scope in the pressure range for 10 µm particle diameter, can profit essentially from 7 µm bulk material. But anyone who have to work in the upper pressure range of with 5 µm phases, can switch to 7 µm particle diameter without any major compromise in terms of separation. VDSpher phases with a particle size of 7 µm are available upon request.

Comparison of pressure and number of theroretical plates per meter for VDSpher® PUR 100 C18-E with particle sizes of 5 µm, 7 µm and 10 µm.

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Welch stationary phase: