QLA for Drug tester accessories

Key considerations

Mesh Openings: One of the biggest problems associated with the basket method involves the clogging of the mesh openings by particles or excipients or the random release of particles through the mesh to the bottom of the vessel. Baskets with a wide variety of mesh openings are available and if the disaggregated particle size is consistent, a variation of mesh size may solve some difficult dissolution problems.

Sintered Mesh: Every QLA stainless steel basket, that conforms to USP, is manufactured using a sintered mesh. Sintering is a strengthening process that compresses and heats the mesh under high pressures and temperatures. This results in welded joints at all the wire overlaps and adds considerable strength and longevity to the basket.

Suppository Baskets: Made from plastic, these baskets have vertical slots instead of mesh to facilitate dissolution. Blocking and/or clogging of the mesh opening is prevented by the use of such a basket, particularly when oil-based suppositories are used.

Compatible with Manufacturer: Agilent/VanKel 

1. 100 Mesh Basket, Agilent/VanKel compatible

Part number: BSK100-01

 

 

 

 

 

Specificationn;

• Basket Mesh: 100
• Cert of Compliance: Yes
• Material: 316 SS
• Serialized: Yes
• UOM/Pack Size: EACH

Fits Bath Models Agilent: 705, 708-DS, 709-DS, VK700/710, VK7000/7010, VK7020 7025 7030 V-Series

2. 40 Mesh Basket, Agilent/VanKel compatible

Part number: BSK040-01

 

 

 

 

 

 

Specificationn;

• Basket Mesh: 40
• Cert of Compliance: Yes
• Material: 316 SS
• Serialized: Yes
• UOM/Pack Size: EACH

Fits Bath Models Agilent: 705, 708-DS, 709-DS, VK700/710, VK7000/7010, VK7020 7025 7030 V-Series

 

Compatible with Manufacturer: Distek

1. 20 Mesh Basket, Distek Evolution compatible

Part number: BSK020-DKC

 

 

 

 

 

 

 

Specificationn;

• Basket Mesh: 20
• Cert of Compliance: Yes
• Material: 316 SS
• Serialized: Yes
• UOM/Pack Size: EACH

Key considerations

Types of Paddles:

Electropolished 316 Stainless Steel: The 316 stainless steel (316 SS) shaft is strong and has a high resistance to bending. It is electropolished for removal of surface impurities and corrosion resistance.

PTFE Coated: The USP suggests that paddles may be coated with an inert coating. Most paddles are accordingly coated with PTFE or another inert coating. If peeling or flaking of the coating is observed then the paddles should be replaced.

Solid Fluoropolymer: The single piece molded design features a fluoropolymer blade and single piece stem molded onto an electropolished 316 SS shaft.

This innovative design features no paddle-to-shaft joint, thus eliminating potential cross-contamination and removing a probable corrosion path. Wobble is also considerably reduced in the solid fluoropolymer paddle because it is a single piece cast.

Compatible with Manufacturer: Agilent/VanKel

1. 15" (380mm) Electropolished SS Paddle, Agilent/VanKel compatible

Part number: EPD015-01

Specifications;

• Cert of Compliance: Yes
• Length inch: 15
• Material: 316 SS
• Serialized: Yes
• UOM/Pack Size: EACH

Fits Bath Models Agilent: VK700/710, VK7000/7010

2. Small Volume Spin ON/OFF Electropolished SS Mini Paddle for Chinese Pharmacopeia

Part number: MINPSHAFT-CP

Specifications;

• Cert of Compliance: Yes
• Material: 316 SS
• Serialized: Yes
• UOM/Pack Size: EACH

Fits Bath Models Agilent: 705, 708-DS, VK700/710, VK7000/7010, VK7020 7025 7030 V-Series

Compatible with Manufacturer: Sotax

1. 11.85" (301mm) Electropolished SS Paddle, Sotax compatible

Part number: EPD012-ST

Specifications;

• Cert of Compliance: Yes
• Length inch: 11.85
• Material: 316 SS
• Serialized: Yes
• UOM/Pack Size: EACH

 

 

Key considerations

Glass Vessels benefit from good thermal conductivity (it is often necessary to have the temperature of the water bath as much as 2°C higher than the analysis temperature when using plastic vessels). Another advantage of using glass vessels is their high resistance to scratching, which means they have to be replaced less frequently.

Amber Vessels can be used if light sensitive compounds are being tested. They are available in glass and plastic. Plastic Vessels are very reproducible because they are made from a mold rather than hand formed. They also have feet which allows them to stand upright independently. The biggest disadvantage is that plastic is very prone to scratching and cracking, requiring frequent replacement.

Plastic vessels have the advantage over glass in that they are very reproducible. The vessel is made from a mold rather than hand-formed. This reduces possible errors in setting the paddle height and centering and can give very reproducible results. Another advantage of plastic vessels is that they have feet so they can stand upright independently.

Plastic Rim Vessels were developed to help minimize glass rim breakage that can occur during normal laboratory use. They are produced by a unique proprietary bonding method using high impact plastic which eliminates rim breakage and safety concerns. All QLA Plastic Rim Vessels are dishwasher safe. Plastic Rim Vessels come in both Standard and UltraCenter™ Precision versions. Serial numbers are laser marked on the plastic rim only. Peak Vessels are designed to prevent cone formation at the base of the vessel. An undesirable poorly stirred cone shaped region can develop under the paddle during USP Apparatus 2 dissolution tests.

Peak vessels have a cone shape molded into the bottom of the vessel that improves the hydrodynamics around the dosage form and leads to more reproducible dissolution rates. The peak effectively displaces the unstirred cone, forcing the material tested into the region of appropriate hydrodynamics, where all surfaces of the dosage are constantly and uniformly exposed to the moving medium. Peak vessels do not comply with USP specifications and cannot be substituted in existing applications.

Compatible with Manufacturer: Agilent/VanKel

1. 1000mL Amber Glass Apex Vessel, Agilent/VanKel compatible

Part number: GLA9PK-AV

Specifications;

• Cert of Compliance: Yes
• Color: AMBER
• Material: BOROSILICATE GLASS
• Serialized: Yes
• UOM/Pack Size: EACVessel Type: Standard Apex
• Volume mL: 1000

Fits Bath Models Agilent: 705, VK700/710, VK7000/7010

2. 2000mL Clear Glass Vessel, Agilent/VanKel compatible

Part number: GLA02K-01

Specifications;

• Cert of Compliance: Yes
• Color: CLEAR
• Material: BOROSILICATE GLASS
• Serialized: Yes
• UOM/Pack Size: EACH
• Vessel Type: Standard
• Volume mL: 2000

Fits Bath Models Agilent: 705, VK700/710, VK7000/7010

Compatible with Manufacturer: Distek

1. 1000mL Amber Premier Glass Vessel, Distek compatible

Part number: GLA900-DKAP

Specifications; 

• Cert of Compliance: Yes
• Color: AMBER
• Material: BOROSILICATE GLASS
• Serialized: Yes
• UOM/Pack Size: EACH
• Vessel Type: Standard
• Volume mL: 1000

Fits Bath Models Distek: 2100 A/B/C, 2500, 5100, 6100, 6300, 7100

2. 1000mL Clear Glass Apex Vessel with Plastic Rim

Part number: GLA9PK-UNP

Specifications;

• Cert of Compliance: Yes
• Color: CLEAR
• Material: BOROSILICATE GLASS
• Serialized: Yes
• UOM/Pack Size: EACH
• Vessel Type: Standard Apex
• Volume mL: 1000

Fits Bath Models Distek: 2100 A/B/C, 2500, 5100, 6100, 6300, 7100

Compatible with Manufacturer: Teledyne Hanson

1. 1000mL Clear Glass Apex Easi-Lock Vessel, Hanson Vision compatible

Part number: GLA9PK-HRV

Specifications;

• Cert of Compliance: Yes
• Color: CLEAR
• Material: BOROSILICATE GLASS
• Serialized: Yes
• UOM/Pack Size: EACH
• Vessel Type: Standard Apex
• Volume mL: 1000

Fits Bath Models Teledyne Hanson: Vision Classic 6, Vision Elite 8

2. 500mL Clear Glass Vessel with Plastic Rim

Part number: GLA500-UNP

Specifications;

• Cert of Compliance: Yes
• Color: CLEAR
• Material: BOROSILICATE GLASS
• New: New
• Serialized: Yes
• UOM/Pack Size: EACH
• Vessel Type: Standard
• Volume mL: 500

Fits Bath Models Teledyne Hanson: SR8/ SR8-Plus

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Key considerations

Sampling Position: The sampling position is important particularly for tests with baskets as there can be a concentration profile between the bottom of the vessel and the stirring element. The sampling position is different for 500mL and 900mL tests. This can create problems for equipment that uses ‘through the shaft’ sampling.

Cannula Length: Cannula vary in length: 4.75” (120mm) is used for 900mL, 7.75” (195mm) is used for 500mL and extended lengths are normally used for ”through the head sampling” whereby the cannula passes through the drive head of the dissolution bath.

Cannula Material: The cannula are made from either stainless steel or PEEK so that they do not absorb or interfere with the active ingredient.

Stoppers: Cannula can be used with stoppers during manual sampling to ensure that the sample is always taken from the same depth. Stoppers are attached to the cannula and sit in a hole in the vessel cover. If these are to be used then it is important to get the stopper and cannula to match the vessel cover type. The range of self-tightening stoppers can be installed and positioned without the need for tools such as screwdrivers. See below for more details.

1. 4.75'' (120mm) Bent 316 SS Cannula with SS Luer Lock & Tygon Tubing for QLA "01" style filters

Part number: CAN475-01

Specifications;

• Length inch: 4.75
• Material: 316 SS
• UOM/Pack Size: EACH
• Volume mL: 900

2. 7.75" (195mm) Bent 316 SS Cannula with SS Luer Lock & Tygon Tubing for QLA "01" style filters

Part number: CAN775-01

Specifications;

• Length inch: 7.75
• Material: 316 SS
• UOM/Pack Size: EACH
• Volume mL: 500

3. 7.75" (195mm) Bent PEEK 1/8" (3.2mm) OD Cannula with PEEK Luer Lock

Part number: CAN775-PH

specifications; 

• Length inch: 7.75
• Material: PEEK
• UOM/Pack Size: EACH
• Volume mL: 500

4. Adjustable Manual 1/8" (3.2mm) OD PEEK Sampling Cannula, Hanson Vision compatible, includes markings at 500mL & 900mL for both Basket & Paddle

Part number: MCAN2-HR

Specifications;

• Diameter: 1/8"
• UOM/Pack Size: EACH

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Types of Filters:

Cannula Filters: Cannula Filters generally have a large surface area and may affect the hydrodynamics in the vessel. However they have a good flow rate and may be used when high levels of particulates are present to prevent particulates blocking the sample probes. A large porosity range is available. Different manufacturers recommend different filters for use with their sampling cannula and not all are interchangeable because of differences in cannula diameter.

Filter Discs: Some low volume sample probes require an In-Line Filter Disc (or filter frit) which has a lower surface area than a cannula filter. These are designed to keep the filtration process outside the vessel but may suffer from blocking due to the lower surface area. These are designed to keep the filtration process outside the vessel but blockages may occur due to the lower surface area.

Filter Tips: Filter Tips are smaller than cannula filters and fit on the end of larger diameter sample probes.

1. 1 Micron Porous Direct Fit Filters, UHMW Polyethylene, (Jar/1000)

Part number: FIL001-VK (Jar/1000), FIL001-VK-a (Pack/100)

Description : Direct Fit-No Tygon Tubing Needed

Specifications;

• Cert of Compliance: Yes
• Filter Porosity micron: 1
• Material: UHMWPE

2. 10 Micron Porous Filters, PVDF

Part number: FIL010-01K (Jar/1000), FIL010-01K-a (Pack/100)

Specifications;

• Cert of Compliance: Yes
• Filter Porosity micron: 10
• Material: PVDF

3. 4 Micron Porous 1/8" ID Filters, UHMW Polyethylene

Part number: FIL004-HR (JAr/1000), FIL004-HR-a (Pack/100)

Specifications;

• Cert of Compliance: Yes
• Filter Porosity micron: 4
• Material: UHMWPE

4. 10 Micron Porous 1/16" ID Filters, UHMW Polyethylene

Part number: FIL10S-HR (JAr/1000), FIL10S-HR-a (Pack/100)

Specifications;

• Cert of Compliance: Yes
• Filter Porosity micron: 10
• Material: UHMWPE

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